Teams (EDIFICE)
Viral Zoonoses and Neglected Tropical Diseases
Coordinator : Stéphanie JACQUET
Members :
Context :
We are currently facing an increase in emerging or re-emerging infectious diseases linked to the amplification of animal and human movements, trade in animal products, as well as environmental and climatic changes caused by population growth and the resulting pressure on natural environments and agroecosystems.
Objectives:
We work to understand the dynamics of the populations of pathogens and to identify the mechanisms of emergence and diffusion of diseases of zoonotic origin affecting human populations that inhabit tropical forest regions in Africa and Asia. Our ultimate objective is to identify strategies aimed at preventing the transmission of pathogens to humans. More specifically, our goal is to develop tools for the early detection of signs of emergence with epidemic potential, mathematical models, as well as health monitoring tools. To do so, we employ an interdisciplinary approach mobilising biological and bioinformatics sciences (genomics, new approaches in serology, cell isolation and culture, field investigation) as well as human sciences.
Keywords:
zoonose – virus – reservoir
Inter-Host Arbovirus Transmission
Coordinator : Julien POMPON
Members:
Context:
Viral diseases transmitted by arthropods are responsible for several hundred million infections every year. Our goal is to understand their transmission in order to promote control strategies.
Objectives:
We aim to: (1) Characterise the molecular mechanisms of transmission by focusing on immune response, pathogenicity, and viral genetics; (2) Develop new control and surveillance strategies based on our discoveries of vaccine and therapeutic targets; (3) Reinforce Southern countries’ capacities and resources by setting up technical platforms; and (4) Characterise the transmission of arboviruses in the field and test new applications. In the context of virus-host-vector interactions, we use tools based on immunology, molecular and cellular biology, reverse genetics, molecular entomology, biochemistry, transcriptomics, proteomics, metabolomics, animal models, and the collection of samples in the field.
Keywords:
Arbovirus – Transmission – Pathophysiology
Chronic Viral Infections: Control and Escape
Coordinator : Avelin AGHOKENG
Context:
The pressure of infectious diseases on populations and healthcare systems is a persistent issue. The team evaluates innovative strategies for screening, diagnosing, treating, and monitoring these infections.
Objectives :
To develop and assess strategies for the control of chronic pathologies linked to infections of major importance for public health, applicable in the existing public healthcare systems of countries where these infections are prevalent.