Teams (PEV)
Virostyle: Evolution and Diversity of Pathogen Lifestyles
Coordinator: Vincent PEDERGNANA
Members:
Context:
Evolution, diversity, and intra- and interspecies interactions in viral and bacterial models; biological information flows and infections
Objectives:
We study intra- and interspecies interactions and changes in the bacterial diversity of vaginal microbiota with the objective of treating bacterial vaginosis through phage therapy. We analyse the impact of host-parasite interactions in the diversity of clinical presentations of viral infections, with a focus on HCV, Dengue virus, HPVs and PyVs. We also endeavour to understand the impact of variations in fidelity during the flow of biological information on infections.
Keywords
Dysbiosis of vaginal microbiota, Phage therapy, Infections and cancers, Viral infections, Fidelity of transmission of biological information
Perturbations, Evolution, and Virulence in Populations and Communities
Coordinator: Christine CHEVILLON
Members:
Context:
Study on the impact of environmental perturbations on host-parasite interactions, from the level of organisms to that of populations and communities.
Objectives:
To understand the risks of disease transmission based on the genetic and phenotypic characteristics of (micro- or macro-) parasites and their vectors (molluscs, arthropods) and the perturbations to which parasite-host-environment systems are subjected. We combine empirical, experimental, and modelling approaches. Our results are intended to lead to practical recommendations for farmers, breeders, and managers in order to help them implement practices capable of limiting the risks of transmission.
https://www.youtube.com/watch?v=oUHynn4fS-s
Keywords
Evolutionary ecology, Health, Virulence, Resistance, Tolerance, Environmental changes, Spatiotemporal heterogeneity, Population biology, Epidemiology, Phylogeography