POSTDOCTORAL OPPORTUNITY ON MOSQUITO METABOLOMICS AT MIVEGEC IRD MONTPELLIER FRANCE
Mosquitoes are the deadliest animals on earth due to their ability to transmit deadly and life-debilitating pathogens. Dengue virus is the most prevalent arthropod-borne virus as it infects about 400 millionpeople yearly and threatens half of the human world population. Unfortunately, there are neither efficient vaccine nor therapeutics and vector control has moderate effect on epidemics.
We recently developed a novel approach based on metabolomics applied to mosquito vector competence (Vial et al. PLoS Pathogens, 2019; doi: 10.1371/journal.ppat.1008199; Vial et al. PNAS, 2020; doi: 10.1073/pnas.2015095117). By combining mosquito metabolomics with molecular entomology and cell biology, we discovered how and why dengue virus reconfigures phospholipids in mosquitoes. This improved understanding of how viruses hijack the host metabolome will be useful to develop novel intervention strategies.
Contact MiVEGEC : Julien POMPON