TITLE: IMPACT OF LIPID METABOLISM ON DENGUE INFECTION AND PATHOGENESIS
PI : Dorothée Missé (IRD, UMR 224 MIVEGEC)
Partners : Institut Pasteur Cambodia (T. Cantaert) and CNRS IRIM (L. Briant & F. Blanchet)
METABODEN is a multidisciplinary project that will explore the interaction between disease severity and host lipid metabolism by studying the dengue virus (DENV)-induced lipid metabolism reprogramming and consequences in pathogenesis. METABODEN aims to (i) identify changes in lipid molecular species and key lipid metabolism enzymes in longitudinal pediatric samples in order to establish a link between DENV-induced blood lipid metabolic imprinting and disease severity, (ii) to decrypt and investigate on molecular mechanisms accounting for DENV- induced lipidome remodeling (iii) to further characterize the role of lipid metabolism and lipidic organelles in myeloid immune cells functions and responses upon DENV infection and (iv) determine the consequences on vascular integrity. Besides increasing fundamental knowledge on the role of lipid metabolism in DENV pathogenesis, METABODEN will also lead to the identification of biomarkers for dengue severity and potential targets for antiviral intervention.