{"id":9906,"date":"2024-06-17T15:09:13","date_gmt":"2024-06-17T13:09:13","guid":{"rendered":"https:\/\/mivegec.fr\/?post_type=project&#038;p=9906"},"modified":"2025-04-23T10:18:30","modified_gmt":"2025-04-23T08:18:30","slug":"projet-anr-metaboden-2024-2028-principale-investigatrice-dorothee-misse","status":"publish","type":"project","link":"https:\/\/mivegec.fr\/fr\/project\/projet-anr-metaboden-2024-2028-principale-investigatrice-dorothee-misse","title":{"rendered":"Projet ANR  METABODEN (2024-2027) PI Doroth\u00e9e Miss\u00e9"},"content":{"rendered":"<h4><strong><em>Impact of lipid metabolism on severe dengue: biomarkers and pathogenesis\u00a0<\/em><\/strong><\/h4>\n<p>La dengue est une arbovirose provoqu\u00e9e par la transmission d\u2019un des quatre s\u00e9rotypes du virus de la dengue par un moustique du genre Aedes. Elle est l\u2019arbovirose la plus fr\u00e9quente dans le monde et est consid\u00e9r\u00e9e comme une infection \u00e9mergente. La lutte contre la dengue n\u00e9cessite une meilleure compr\u00e9hension des m\u00e9canismes pathophysiologiques impliqu\u00e9s dans la transition vers une maladie mortelle et la d\u00e9finition de nouvelles cibles permettant une intervention th\u00e9rapeutique. L\u2019hypoth\u00e8se de METABODEN postule que le m\u00e9tabolisme lipidique joue un r\u00f4le majeur dans la pathog\u00e9nie de la dengue. Notre programme caract\u00e9risera le lien entre l\u2019empreinte m\u00e9tabolique sanguine et la s\u00e9v\u00e9rit\u00e9 de la maladie \u00e0 l\u2019aide d\u2019\u00e9chantillons cliniques p\u00e9diatriques longitudinaux et d\u2019approches m\u00e9tabolomiques. Il analysera les interactions h\u00f4te\/DENV induisant le remodelage du lipidome de l\u2019h\u00f4te en vue d\u2019identifier des cibles th\u00e9rapeutiques. Enfin, METABODEN \u00e9tudiera les cons\u00e9quences pathog\u00e9niques du remodelage du lipidome de l\u2019h\u00f4te sur la r\u00e9ponse immunitaire inn\u00e9e, et la perm\u00e9abilit\u00e9 vasculaire. En plus d&rsquo;accro\u00eetre les connaissances fondamentales relatives aux interactions entre le m\u00e9tabolisme lipidique et la pathogen\u00e8se de la dengue, METABODEN identifiera des biomarqueurs fiables, pour pr\u00e9dire la gravit\u00e9 de la maladie, ainsi que des cibles th\u00e9rapeutiques.<\/p>\n<p><strong><em>Partenaires\u00a0:<\/em><\/strong><em> IRD, Institut Pasteur du Cambodge, CNRS IRIM, Universit\u00e9s de Mahidol et de Chiang Mai (Tha\u00eflande). <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Impact of lipid metabolism on severe dengue: biomarkers and pathogenesis\u00a0 La dengue est une arbovirose provoqu\u00e9e par la transmission d\u2019un des quatre s\u00e9rotypes du virus de la dengue par un moustique du genre Aedes. Elle est l\u2019arbovirose la plus fr\u00e9quente dans le monde et est consid\u00e9r\u00e9e comme une infection \u00e9mergente. La lutte contre la dengue [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[37],"project_tag":[],"class_list":["post-9906","project","type-project","status-publish","hentry","project_category-ds5"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Projet ANR METABODEN (2024-2027) PI Doroth\u00e9e Miss\u00e9 - MIVEGEC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mivegec.fr\/fr\/project\/projet-anr-metaboden-2024-2028-principale-investigatrice-dorothee-misse\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Projet ANR METABODEN (2024-2027) PI Doroth\u00e9e Miss\u00e9 - MIVEGEC\" \/>\n<meta property=\"og:description\" content=\"Impact of lipid metabolism on severe dengue: biomarkers and pathogenesis\u00a0 La dengue est une arbovirose provoqu\u00e9e par la transmission d\u2019un des quatre s\u00e9rotypes du virus de la dengue par un moustique du genre Aedes. 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